课题组负责人

温振科博士，博导

苏州大学特聘教授  

温振科教授，2004年获山东第一医科大学（原泰山医学院）医学学士学位，2007年获复旦大学上海医学院医学硕士学位，2007-2010年任青岛市中心血站医师、副主任，2013年获复旦大学上海医学院医学博士学位，2013-2014年任美国西奈山医学院博士后，2014-2019年任美国斯坦福大学医学院博士后、Research Scientist。2019年9月加盟苏州大学新安棋牌，任特聘教授、博导。迄今为止，已在Nat Immunol、Sci Transl Med、Immunity、Cell Metab、J Clin Invest、Arthritis Rheumatol和J Immunol等发表SCI研究论文30余篇，总引用>1000次；同时担任Mol Ther Nucleic Acids和Front Immunol等20本SCI期刊审稿人。

研究方向

随着人口老龄化的不断加剧，自身免疫性疾病和肿瘤等慢性难治性疾病成为困扰人类健康的关键难题。我们的研究聚焦在三个方面：

（1）难治性自身免疫性疾病的免疫学基础及应对策略；

（2）肿瘤微环境中的免疫调节和靶向干预；

（3）免疫衰老分子机制与健康衰老。  

近期代表性论文  

1.Zhang J, Zhao L, Wang J, Cheng Z, Sun M, Zhao J, Liu B, Liu X#, Wen Z#, Li Z#. Targeting the mechanistic target of rapamycin complex 1 restricts pro-inflammatory T cell differentiation and ameliorates Takayasu's arteritis. Arthritis Rheumatol, 2019; doi: 10.1002/art.41084.

2.Li Y, Shen Y, Jin K, Wen Z, Cao W, Wu B, Wen R, Tian L, Berry GJ, Goronzy JJ, Weyand CM. The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation. Cell Metab, 2019; 30(3):477-492.

3.Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, Tian L, Shoor S, Roche NE, Goronzy JJ, Weyand CM. N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation. Nat Immunol, 2019; 20:313-325. (Comments in Nat Immunol and Nat Rev Rheumatol)

4.Wen Z, Shen Y, Berry G, Shahram F, Li Y, Watanabe R, Liao YJ, Goronzy JJ, Weyand CM. The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway. Sci Transl Med, 2017; 9(399). pii: eaal3322. (Highlighted Article, Comment in Nat Rev Rheumatol)

5.Shen Y, Wen Z, Li Y, Matteson EL, Hong J, Goronzy JJ, Weyand CM. Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells. Nat Immunol, 2017; 18(9):1025-1034. (Cover Story, Comment in Nat Immunol, F1000Prime Recommended Article)

6.Wen Z*, Shimojima Y*, Shirai T, Li Y, Ju J, Yang Z, Tian L, Goronzy JJ, Weyand CM. NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs. J Clin Invest, 2016; 126:1953-67. (Highlighted Article, Comments in J Clin Invest and Nat Rev Rheumatol, F1000Prime Recommended Article)

7.Li Y, Shen Y, Hohensinner P, Ju J, Wen Z, Goodman SB, Zhang H, Goronzy JJ, Weyand CM. Deficient activity of the nuclease MRE11A induces T cell aging and promotes arthritogenic effector functions in patients with rheumatoid arthritis. Immunity, 2016; 45:903-916. (Comment in Nat Rev Rheumatol)

8.Bu X, Zhang T, Wang C, Ren T#, Wen Z#. IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production. J Transl Med, 2015; 13:381.

9.Hu Y, Wang C, Li Y, Zhao J, Chen C, Zhou Y, Tao Y, Guo M, Qin N, Ren T, Wen Z#, Xu L#. MiR-21 controls in situ expansion of CCR6+ regulatory T cells through PTEN/AKT pathway in breast cancer. Immunol Cell Biol, 2015; 93:753-64.

10.Wen Z, Xu L, Chen X, Xu W, Yin Z, Gao X, Xiong S. Autoantibody Induction by DNA-Containing Immune Complexes Requires HMGB1 with the TLR2/MicroRNA-155 Pathway. J Immunol, 2013; 190:5411-22. (Comment in Nat Rev Rheumatol, F1000Prime Recommended Article)

11.Guo Z*, Wen Z*, Qin A*, Zhou Y, Liao Z, Liu Z, Liang Y, Ren T, Xu L. Antisense Oligonucleotide Treatment Enhances the Recovery of Acute Lung Injury through IL-10-Secreting M2-like Macrophage-Induced Expansion of CD4+ Regulatory T Cells. J Immunol, 2013; 190:4337-48.

E-mail：zkwen@suda.edu.cn

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