课题组负责人

周芳芳博士 特聘教授 博导

周芳芳教授，2008年在清华大学生物科学与技术系获得博士学位。2008-2013年在荷兰莱顿大学医学中心从事博士后研究。 2013-2014年在荷兰莱顿大学医学中心任研究助理教授。2014年10月受聘苏州大学新安棋牌特聘教授及博士生导师。周芳芳教授长期致力于细胞信号转导，包括TGF-β，Wnt，NF-κB等信号通路的分子机制的研究以及在人类疾病特别是肿瘤发生发展中细胞信号紊乱导致的影响，并取得了多项科研成果。以第一或通讯家胜棋牌身份在国际著名期刊如Nature Immunology、Nature Cell Biology、Molecular Cell、EMBO Journal、Nature Communications、Trends in Biochemical Sciences及Molecular Biology of the Cell, The Journal of Biological Chemistry等发表论文20余篇。目前，周芳芳教授及其团队致力于肿瘤与免疫的互作及分子机制的研究。

主要研究方向：

1、先天免疫与其他信号通路（TGF-β、Wnt、Hippo/Yap）间的互作（cross-talk)及其生理意义；

2、肿瘤细胞转移过程中逃脱免疫监视的分子机制；

代表性论文 （#Corresponding author; *Co-first authors）

1. Wang S, Xie F, Chu F, Zhang Z, Yang B, Dai T, Gao L, Wang L, Ling L, Jia J, van Dam H, Jin J, Zhang L#, Zhou F#. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation. Nat Immunol. 2017

2. Xie F, Jin K, Shao L, Fan Y, Tu YF, Yang B, van Dam H, Ten Dijke P, Weng HL, Dooley S, Wang S, Jia JL, Jin J,Zhou F#, Zhang L#. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nat Commun. 2017

3. Zhou F, Xie F, Jin K, Zhang ZK, Clerici M, Gao R, Sixma TK, Huang HZ, van Dinther M, Zhang L#, Ten Dijke P#. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO J.2017

4. Zhang L#, Xie F, Ten Dijke P,  Zhang J, Zhou F#. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death Differ. 2017 (In press)

5. Jin K#, Li T, van Dam H, Zhou F#, Zhang L#. Molecular insight into tumor metastasis: tracing the dominant events. J Pathol. 2016

6. Jin K#, Li T, Sanchez-Duffhues G, Zhou F#, Zhang L#. Involvement of inflammation and its related microRNAs in hepatocellular carcinoma. Oncotarget. 2016

7. Li Y, Jin K, van Pelt GW, van Dam H, Yu X, Mesker WE, Ten Dijke P, Zhou F#, Zhang L#. c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway. Cancer Res. 2016

8. Zhou F, Li F, Fang P, Dai T, Yang B, van Dam H, Jia J, Zheng M, Zhang L. Ubiquitin-Specific Protease 4 Antagonize Osteoblast Differentiation through Dishevelled. J Bone Miner Res. 2016

9. Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L#,Zhou F#. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell. 2014

10. Zhou F, Drabsch Y, Dekker T.J.A, Vinuesa A.G.d, Li Y,Hawinkels L.J, Lu CX, Zhang L, Ten Dijke P. (2014) Nuclearreceptor NR4A1 promotes breast cancer invasion and metastasis by activatingTGF-β signalling. Nat Commun. 2014

11. Zhang L#, Zhou F#, ten Dijke P#. (2013) Signaling interplay between transforming growthfactor-β receptor and PI3K/AKT pathways in cancer. Trends Biochem Sci.2013

12. Zhang L*, Zhou F*#, García de Vinuesa A, de Kruijf EM, Mesker WE, HuiL, Drabsch Y, Li Y, Bauer A, Rousseau A, Sheppard KA, Mickanin C, Kuppen PJ, LuCX, Ten Dijke P#.(2013) TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Molecular Cell. 51(5):559–572.

13. Zhou F, Zhang XF, van Dam H, ten Dijke P, Huang HZ, Zhang L. Ubiquitin-specificprotease 4 mitigates Toll-like/Interleukin-1 receptor signaling and regulatesinnate immune activation. J Biol Chem. 2012

14. Zhang L*#, Huang H*, Zhou F*, Pardo CG, Zhang T, Barakat TS, Sheppard KA, van Dam H, Gribnau J, Lu C, and ten Dijke P#. RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Molecular Cell 2012; 

15. Zhang L*,Zhou F*#, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H, Sheppard KA, Lu C,and ten Dijke P#. (2012) USP4is regulated by Akt phosphorylation and directly deubiquitinates TGF-β type Ireceptor. Nat Cell Biol. 2012

16. Zhang L*, Zhou F*#, van Laar T, Zhang J, van Dam H, ten Dijke P#. Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation. Mol Biol Cell. 2011;

17. Zhou F*, Zhang L*#, van Laar T, van Dam H, ten Dijke P#. GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb. Mol Biol Cell. 2011;

18. Zhou F*, Zhang L*, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong. The association of GSKβ with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J Biol Chem. 2008; 

课题组成员

王帅 副研究员 硕导

王帅博士于2010年获得山东大学生物化学与分子生物学博士学位。2010年加中国科学院武汉病毒研究所担任助理研究员职位。2013年加入苏州大学新安棋牌，目前担任周芳芳课题组副研究员职位。

谢枫 师资博士后

谢枫于2017年3月获浙江大学细胞生物学专业博士学位，同年成为周芳芳教授课题组博士后，并获得国家“博新计划”资助。

褚峰 助理研究员

褚峰于2014年获得苏州大学发育生物学专业硕士学位，同年加入苏州大学周芳芳教授课题组担任技术员职位。

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